Journal
JOURNAL OF NEUROSCIENCE
Volume 27, Issue 7, Pages 1594-1605Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4205-06.2007
Keywords
nucleus accumbens; ventral pallidum; opioid; hedonic; reward; motivation; eating; food intake; Fos
Categories
Funding
- NIDA NIH HHS [DA015188] Funding Source: Medline
- NIDCD NIH HHS [DC010011] Funding Source: Medline
- NIMH NIH HHS [MH63649] Funding Source: Medline
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mu-Opioid stimulation of cubic millimeter hedonic hotspots in either the nucleus accumbens shell (NAc) or the ventral pallidum (VP) amplifies hedonic liking reactions to sweetness and appetitive wanting for food reward. How do these two NAc-VP hotspots interact? To probe their interaction and limbic circuit properties, we assessed whether opioid activation of one hotspot recruited the other hotspot (neurobiologically) and whether opioid hedonic and incentive motivational amplification by either opioid hotspot required permissive opioid coactivation in the other (behaviorally). We found that NAc and VP hotspots reciprocally modulated Fos expression in each other and that the two hotspots were needed together to enhance sucrose liking reactions, essentially cooperating within a single hedonic NAc-VP circuit. In contrast, the NAc hotspot dominated for opioid stimulation of eating and food intake (wanting), independent of VP activation. This pattern reveals differences between limbic opioid circuits that control reward liking and wanting functions.
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