N-ortho-Ferrocenyl benzoyl dipeptide esters:: Synthesis, structural characterization and in vitro anti-cancer activity of N-{ortho-(ferrocenyl)benzoyl}-glycine-L-alanine ethyl ester and N-{ortho-(ferrocenyl)benzoyl}-L-alanine-glycine ethyl ester

N-ortho-ferrocenyl benzoyl dipeptide esters 2-6 were prepared by coupling ortho-ferrocenyl benzoic acid I to the dipeptide ethyl esters GlyGly(OEt) (2), GlyAla(OEt) (3), GlyPhe(OEt) (4), AlaGly(OEt) (5) and AlaPhe(OEt) (6). The compounds were fully characterized by a range of NMR spectroscopic techniques, mass spectrometry and cyclic voltammetry. The cytotoxicity of 3 and 5 towards lung cancer cells has been determined. (C) 2006 Elsevier B.V. All rights reserved.