Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 12, Pages 3070-3095Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201302195
Keywords
biocatalysis; bioorganic chemistry; enzyme catalysis; synthetic methods
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The use of enzymes as catalysts for the preparation of novel compounds has received steadily increasing attention over the past few years. High demands are placed on the identification of new biocatalysts for organic synthesis. The catalysis of more ambitious reactions reflects the high expectations of this field of research. Enzymes play an increasingly important role as biocatalysts in the synthesis of key intermediates for the pharmaceutical and chemical industry, and new enzymatic technologies and processes have been established. Enzymes are an important part of the spectrum of catalysts available for synthetic chemistry. The advantages and applications of the most recent and attractive biocatalystsreductases, transaminases, ammonia lyases, epoxide hydrolases, and dehalogenaseswill be discussed herein and exemplified by the syntheses of interesting compounds.
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