Journal
GENES & DEVELOPMENT
Volume 21, Issue 4, Pages 367-378Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1504307
Keywords
retinal development; degeneration and regeneration; retinal ganglion cells; axon guidance; topographic mapping; neurotrophins; cancer
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Funding
- NINDS NIH HHS [R37NS33199] Funding Source: Medline
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Vertebrate eye development has been an excellent model system to investigate basic concepts of developmental biology ranging from mechanisms of tissue induction to the complex patterning and bidimensional orientation of the highly specialized retina. Recent advances have shed light on the interplay between numerous transcriptional networks and growth factors that are involved in the specific stages of retinogenesis, optic nerve formation, and topographic mapping. In this review, we summarize this recent progress on the molecular mechanisms underlying the development of the eye, visual system, and embryonic tumors that arise in the optic system.
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