Synthesis and characterization of stimuli-sensitive micro- and nanohydrogels based on photocrosslinkable poly(dimethylaminoethyl methacrylate)

The aim of this work was the development of a versatile route for the preparation of temperature- and pH-responsive hydrogels with small dimensions. The copolymerization of N,N-dimethylaminoethyl methacrylate with various amounts (5 and 10 mol %) of dimethylmaleimidoethyl methacrylate in solution with 2,2'-azobisisobutyronitrile as an initiator is described. The structural and molecular characterization of the copolymers was performed with proton nuclear magnetic resonance, Fourier transform infrared, and ultraviolet spectroscopy, as well as size exclusion chromatography. Differential scanning calorimetry and thermogravimetry were used for the thermal characterization of the copolymers. Micro- and nanohydrogels of the copolymers were prepared by photocrosslinking. The gels obtained by photocrosslinking were characterized with a combination of surface plasmon resonance and optical waveguide spectroscopy, dynamic light scattering, and scanning electron microscopy. The hydrogels showed temperature-and pH-responsive behavior. (c) 2006 Wiley Periodicals, Inc.