Journal
BIOLOGICAL PSYCHIATRY
Volume 61, Issue 4, Pages 429-437Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2006.06.020
Keywords
association; autism spectrum disorder; candidate genes; cytogenetics; genetics; linkage
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Funding
- NCRR NIH HHS [K23 RR16118] Funding Source: Medline
- NIMH NIH HHS [T32 MH18268] Funding Source: Medline
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Autism is a strongly genetic disorder with an estimated heritability of greater than. 90%. Nonetheless, its specific genetic etiology remains largely unknown. Over the past several years, the convergence of rapidly advancing genomic technologies, the completion to the human genome project, and succesful collaborative efforts to increase the number of deoxyribonucleic acid samples available for study have led to the first solid clues regarding the genetic origins of autism spectrum disorders. This article addresses the obstacles that have confronted gene discovery efforts and reviews recent linkage, cytogenetic, and candidate gene association studies relevant to autism, spectrum disorders. In addition, promising avenues for future research and the potential contribution of emerging genomic technologies are considered.
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