Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 31, Pages 8127-8131Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201401035
Keywords
bacteria; bimetallic nanoparticles; gold; platinum
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Funding
- Ministry of Science and Technology [2012AA022703, 2012AA030308, 2011CB933201]
- Chinese Academy of Science [NNCAS-2010-5, XDA09030305]
- National Science Foundation of China [21025520, 91213305, 21222502, 81361140345, 51373043]
- Beijing Natural Science Foundation [2122058]
- Beijing Municipal Science and Technology Commission [Z131100002713024]
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We show that bimetallic nanoparticles (NPs) of AuPt without any surface modification are potent antibiotic reagents, while pure Au NPs or pure Pt NPs display no antibiotic activities. The most potent antibacterial AuPt NPs happen to be the most effective catalysts for chemical transformations. The mechanism of antibiotic action includes the dissipation of membrane potential and the elevation of adenosine triphosphate (ATP) levels. These bimetallic NPs are unique in that they do not produce reactive oxygen species as most antibiotics do. Being non-toxic to human cells, these bimetallic noble NPs might open an entry to a new class of antibiotics.
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