Journal
IMMUNOLOGY LETTERS
Volume 108, Issue 2, Pages 183-188Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2006.12.007
Keywords
CpG DNA; costimulation; CD4+CD25+regulatory T cells
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Funding
- NIAID NIH HHS [P01 AI043620, R01 AI062789, AI-43620] Funding Source: Medline
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Toll-like receptor (TLR) ligands are notable for their ability to induce APC maturation, which in turn facilitates optimal T cell mediated immune responses. Toll-like receptor ligands, such as CpG DNA, can also modulate immune responses by blocking the suppressive effects of CD4+CD25+ regulatory T cells (Tregs). Recently, we have demonstrated that CpG DNA, in addition to its actions on APCs and Tregs, can provide direct costimulatory signals to CD4+CD25- T cells. Here we show that this costimulatory effect is sufficient to abrogate suppression by Tregs. These data indicate a previously undefined role for TLR ligands in directly modulating CD4+ T cell responses. (c) 2007 Elsevier B.V. All rights reserved.
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