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An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer

Journal

CANCER RESEARCH
Volume 67, Issue 4, Pages 1407-1410

Publisher

AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-06-2149

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Funding

  1. NCRR NIH HHS [P20 RR 17698-01] Funding Source: Medline

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Nitric oxide (NO) is a free radical that is involved in carcinogenesis. Recent literature indicates that endothelial NO synthase (eNOS) can modulate cancer-related events (angiogenesis, apoptosis, cell cycle, invasion, and metastasis). We review the literature linking eNOS to carcinogenesis to encourage future research assessing the role of eNOS in cancer prevention and treatment.

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