Journal
BRAIN RESEARCH
Volume 1133, Issue 1, Pages 49-52Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2006.11.072
Keywords
biomarker; oxidative stress; 8-OHdG; Parkinson's disease; neurodegeneration
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8-Hydroxy-2'-deoxyguanosine (8-OHdG), the predominant marker of oxidative DNA damage, may be a good biomarker for monitoring the progression of Parkinson's disease (PD). Unfortunately, there are no basic laboratory data examining 8-OHdG levels in animal models of PD. In this study, we demonstrate that rats lesioned with 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle display significantly elevated 8-OHdG levels in urine, serum, and substantia nigra, but not cerebrospinal fluid and striatum, compared to sham controls. These increments in 8-OHdG levels were detected at 2 days, but not at 7 days after the lesion suggesting that oxidative stress is restricted to the acute phase of 6-OHDA neurotoxicity. The present results support 8-OHdG as a biomarker that may aid both in the diagnosis and in the documentation of progression in PD. (c) 2006 Elsevier B.V. All rights reserved.
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