Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 6, Pages 1770-1774Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201408472
Keywords
antitumor agents; oxygen; photodynamic therapy; radiotherapy; semiconductors
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Funding
- National Natural Science Foundation of China [51372260, 51132009, 21172043]
- Shanghai Rising-Star Program [12QH1402500]
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Strong oxygen dependence and limited penetration depth are the two major challenges facing the clinical application of photodynamic therapy (PDT). In contrast, ionizing radiation is too penetrative and often leads to inefficient radiotherapy (RT) in the clinic because of the lack of effective energy accumulation in the tumor region. Inspired by the complementary advantages of PDT and RT, we present herein the integration of a scintillator and a semiconductor as an ionizing-radiation-induced PDT agent, achieving synchronous radiotherapy and depth-insensitive PDT with diminished oxygen dependence. In the core-shell Ce-III-doped LiYF4@SiO2@ZnO structure, the downconverted ultraviolet fluorescence from the Ce-III-doped LiYF4 nanoscintillator under ionizing irradiation enables the generation of electron-hole (e(-)-h(+)) pairs in ZnO nanoparticles, giving rise to the formation of biotoxic hydroxyl radicals. This process is analogous to a typeI PDT process for enhanced antitumor therapeutic efficacy.
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