Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 353, Issue 3, Pages 547-552Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2006.12.061
Keywords
p120-catenin; neuronal cells; calpain; aggregation; ischemia; MDL28170
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p120-catenin contributes to the cadherin-mediated adhesion and aggregation of cells. g-Calpain was activated and p120-catenin was degraded after 36 h of ischemia in differentiated SH-SY5Y cells. Calpain inhibitors Cbz-Val-Phe-H (MDL28170, 20 mu M) and N-acetyl-leucyl-leucyl-norleucinal (ALLN, 20 mu M) increased the levels of dephosphorylated p120-catenin, aggregation, and cell survival as detected by reduced LDH release in ischemic cells. However, a proteasome inhibitor lactacystin had no such effects. This is the first report of the calpain-mediated degradation of p120-catenin and an association between the level of dephosphorylated p120-catenin and cell aggregation in ischemic neuronal cells. (c) 2006 Elsevier Inc. All rights reserved.
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