Journal
SCIENCE
Volume 315, Issue 5814, Pages 988-992Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1136606
Keywords
-
Categories
Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIDDK NIH HHS [R56 DK090078] Funding Source: Medline
Ask authors/readers for more resources
The adult Drosophila midgut contains multipotent intestinal stem cells (ISCs) scattered along its basement membrane that have been shown by lineage analysis to generate both enterocytes and enteroendocrine cells. ISCs containing high levels of cytoplasmic Delta-rich vesicles activate the canonical Notch pathway and down-regulate Delta within their daughters, a process that programs these daughters to become enterocytes. ISCs that express little vesiculate Delta, or are genetically impaired in Notch signaling, specify their daughters to become enteroendocrine cells. Thus, ISCs control daughter cell fate by modulating Notch signaling over time. Our studies suggest that ISCs actively coordinate cell production with local tissue requirements by this mechanism.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available