Journal
SCIENCE
Volume 315, Issue 5814, Pages 1006-1010Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1137306
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Funding
- NIAMS NIH HHS [R01 AR48114, K08 AR2214] Funding Source: Medline
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The normal synovium forms a membrane at the edges of joints and provides lubrication and nutrients for the cartilage. In rheumatoid arthritis, the synovium is the site of inflammation, and it participates in an organized tissue response that damages cartilage and bone. We identified cadherin-11 as essential for the development of the synovium. Cadherin-11-deficient mice have a hypoplastic synovial lining, display a disorganized synovial reaction to inflammation, and are resistant to inflammatory arthritis. Cadherin-11 therapeutics prevent and reduce arthritis in mouse models. Thus, synovial cadherin-11 determines the behavior of synovial cells in their proinflammatory and destructive tissue response in inflammatory arthritis.
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