Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 41, Pages 11010-11014Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201403711
Keywords
amines; carbon dioxide; homogeneous catalysis; hydrogenation; methylation
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Funding
- Cluster of Excellence Tailor-Made Fuels from Biomass - Excellence Initiative by the German Federal Government
- Cluster of Excellence Tailor-Made Fuels from Biomass - Excellence Initiative by the German State Government
- project Sustainable Chemical Synthesis (SusChemSys)
- European Regional Development Fund (ERDF)
- state of North Rhine-Westphalia (Germany), under the operational program Regional Competitiveness and Employment
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The use of the well-defined [Ru(triphos)(tmm)] catalyst, CO2 as C-1 source, and H-2 as reducing agent enabled the reductive methylation of isolated imines, as well as the direct coupling of amines with aldehydes and the subsequent reductive methylation of the in situ formed imines. The method, which afforded the corresponding N-methyl amines in very good to excellent yields, was also used for the preparation of the antifungal agent butenafine in one step with no apparent waste, thus increasing the atom efficiency of its synthesis.
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