Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 1, Pages 144-148Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201409356
Keywords
continuous processing; flow reactors; integrated systems; synthetic methods
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Funding
- Ralph Raphael Scholarship
- Woolf Fisher Trust
- UK Engineering and Physical Sciences Research Council
- Pfizer Worldwide Research and Development
- Engineering and Physical Sciences Research Council [EP/K009494/1] Funding Source: researchfish
- EPSRC [EP/K009494/1] Funding Source: UKRI
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Performing reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi-step process. Using new modular components for downstream processing, coupled with control technologies, more advanced multi-step flow sequences can be realized. These tools are applied to the synthesis of 2-aminoadamantane-2-carboxylic acid. A system comprising three chemistry steps and three workup steps was developed, having sufficient autonomy and self-regulation to be managed by a single operator.
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