Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 52, Issue 50, Pages 13154-13161Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201303529
Keywords
DNA sequencing; ion channels; membrane proteins; nanopores; single-molecule studies
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Funding
- National Base Research 973 Program [2013CB733700]
- National Science Fund of China [21125522, 21327807, SKLEAC201305]
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Nanopore-based techniques, which mimic the functions of natural ion channels, have attracted increasing attention as unique methods for single-molecule detection. The technology allows the real-time, selective, high-throughput analysis of nucleic acids through both biological and solid-state nanopores. In this Minireview, the background and latest progress in nanopore-based sequencing and detection of nucleic acids are summarized, and light is shed on a novel platform for nanopore-based detection.
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