Journal
FEBS LETTERS
Volume 581, Issue 4, Pages 673-680Publisher
WILEY
DOI: 10.1016/j.febslet.2007.01.028
Keywords
angiogenesis; shear stress; endothelium; Foxo-1; Ang-2; Tie2
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Transcription factor Foxo-1 can be inactivated via Akt-mediated phosphorylation. Since shear stress activates Akt, we determined whether Foxo-1 and the Foxo-1 -dependent, angiogenesis-related Ang-2/Tie2-system are influenced by shear stress in endothelial cells. Expression of Foxo-1 and its target genes p27Kip1 and Ang-2 was decreased under shear stress (6 dyn/cm(2), 24 h), nuclear exclusion of Foxo-I by phosphorylation increased. eNOS and Tie2 were upregulated. No effects on Ang-1 expression were detected. In conclusion, Foxo-1 and Ang-2/Tie2 are part of the molecular response to shear stress, which may regulate angiogenesis. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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