Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 46, Issue 6, Pages 2656-2662Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2015.2945
Keywords
human papillomavirus; CADM1; hypermethylation; cervical cancer
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Funding
- Korea National Institute of Health, Ministry of Health and Welfare, Republic of Korea [2013-NG51003-00]
- Korea Health Promotion Institute [2013-NG51003-00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Epigenetic modification at CpG islands located on the promoter regions of tumor-suppressor genes has been associated with tumor development in many human cancers. Our study showed that the cell adhesion molecule 1 (CADM1) is downregulated in human papillomavirus (HPV)-infected cervical cancer cell lines via its hypermethylation and demethylation using 5-aza-2'-deoxycyticine (5-aza-dC) restored the expression of CADM1 protein. Overexpression of CADM1 inhibited cell proliferation. p53 was involved in the regulation of CADM1. Our results demonstrate that epigenetic alteration of CADM1 was more frequent in HPV-positive cervical cancers and that restoration of CADM1 expression may be a potential strategy for cervical cancer therapy.
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