Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 129, Issue 7, Pages 1884-+Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ja068154n
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A series of peptide-dendron conjugates, based on an intrinsically alpha-helical, alanine-rich sequence, were constructed to explore how the conformational equilibria of each structural element can be conformationally coupled. The interdendron spacing was varied from i, i + 4 (2) to i, i +11 (9) to probe how the nature of the dendron interaction impacted the conformational properties. These studies revealed an alpha-helix to beta-sheet conformational transition that occurred in water for peptide-dendron conjugates 4 (i, i + 6) and 8 (i, i + 10). Chiral transfer from the peptide backbone to the dendron helicity emerges only in the beta-sheet forms of 4 and 8, revealing a synergistic coupling of the conformations of both structural elements.
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