Journal
EMBO JOURNAL
Volume 26, Issue 4, Pages 1150-1162Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.emboj.7601546
Keywords
NF-kappa B; p65 acetylation; PKA; Smad; TGF-beta 1
Categories
Funding
- NCI NIH HHS [CA108454, R01 CA108454] Funding Source: Medline
- NHLBI NIH HHS [P01 HL077789, HL077789] Funding Source: Medline
- NIDCD NIH HHS [DC005843, DC004562, R01 DC005843, R01 DC004562] Funding Source: Medline
- NIGMS NIH HHS [GM063773, R01 GM063773] Funding Source: Medline
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Transforming growth factor-beta (TGF-beta) family members are multifunctional growth factors involved in regulating diverse biological processes. Despite the critical role for TGF-beta in regulating cell proliferation, differentiation, migration and development, its role in regulating NF-kappa B-dependent inflammatory response still remains unclear. Here, we show that TGF-beta 1 induces acetylation of NF-kappa B p65 subunit to synergistically enhance bacterium non-typeable Haemophilus influenzae-induced NF-kappa B activation and inflammatory response in vitro and in vivo. The TGF-beta 1-induced acetylation of p65 is mediated via a Smad3/4-PKA-p300-dependent signaling pathway. Acetylation of p65 at lysine 221 by TGF-b1 is critical for synergistic enhancement of bacteria-induced DNA-binding activity, NF-kappa B activation, NF-kappa B-dependent transcription of TNF-beta and IL-1 beta and interstitial polymorphonuclear neutrophil infiltration in vitro and in vivo. These studies provide new insights into the novel regulation of NF-kappa B by TGF-beta signaling.
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