Journal
JOURNAL OF NEUROSCIENCE
Volume 27, Issue 8, Pages 2025-2034Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4301-06.2007
Keywords
BST; corticotropin-releasing hormone; vasopressin; paraventricular nucleus of the hypothalamus; corticosterone; ACTH
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Funding
- NIDA NIH HHS [DA16466] Funding Source: Medline
- NIDDK NIH HHS [DK67820, DK59803] Funding Source: Medline
- NIMH NIH HHS [MH49698] Funding Source: Medline
- NINDS NIH HHS [NS07453] Funding Source: Medline
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Limbic and cortical neurocircuits profoundly influence hypothalamic - pituitary - adrenal ( HPA) axis responses to stress yet have little or no direct projections to the hypothalamic paraventricular nucleus ( PVN). Numerous lines of evidence suggest that the bed nucleus of the stria terminalis ( BST) is well positioned to relay limbic information to the PVN. The BST comprises multiple anatomically distinct nuclei, of which some are known to receive direct limbic and/ or cortical input and to heavily innervate the PVN. Our studies test the hypothesis that subregions of the BST differentially regulate HPA axis responses to acute stress. Male Sprague Dawley rats received bilateral ibotenate lesions, targeting either the principal nucleus in the posterior BST or the dorsomedial/ fusiform nuclei in the anteroventral BST. Posterior BST lesions elevated plasma ACTH and corticosterone in response to acute restraint stress, increased stress- induced PVN c-fos mRNA, and elevated PVN corticotropin- releasing hormone ( CRH) and parvocellular arginine vasopressin ( AVP) mRNA expression relative to sham- lesion animals. In contrast, anterior BST lesions attenuated the plasma corticosterone response and decreased c- fos mRNA induction in the PVN but did not affect CRH and parvocellular AVP mRNA expression in the PVN. These data suggest that posterior BST nuclei are involved in inhibition of the HPA axis, whereas the anteroventral BST nuclei are involved in HPA axis excitation. The results indicate that the BST contains functional subdomains that play different roles in integrating and processing limbic information in response to stress and further suggest that excitatory as well as inhibitory limbic information is funneled through these important cell groups.
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