Journal
STATISTICS IN MEDICINE
Volume 26, Issue 5, Pages 954-964Publisher
WILEY
DOI: 10.1002/sim.2663
Keywords
as treated; clinical trial; instrumental variables; intent-to-treat; non-compliance; per protocol; treatment effect
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In this report, we compared four estimators (intent-to-treat; as treated, per protocol, and instrumental variables estimators) that are conventionally considered for treatment effect estimation by simulation under different non-compliance scenarios in typical clinical trial settings. We found that intent-to-treat and instrumental variables estimators are not perfect and can be problematic in some situations although these two estimators carry desirable properties as we assume. Copyright 2006 John Wiley & Sons, Ltd.
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