Journal
STATISTICS IN MEDICINE
Volume 26, Issue 5, Pages 1150-1169Publisher
WILEY
DOI: 10.1002/sim.2602
Keywords
Bayesian; interaction; meta-analysis; asbestos; smoking; lung cancer
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We review the literature on the combined association between lung cancer and two environmental exposures, asbestos exposure and smoking, and explore a Bayesian approach to assess evidence of interaction between the exposures. The meta-analysis combines separate indices of additive and multiplicative relationships and multivariate relative risk estimates. By making inferences on posterior probabilities we can explore both the form and strength of interaction. This analysis may be more informative than providing evidence to support one relation over another on the basis of statistical significance. Overall, we find evidence for a more than additive and less than multiplicative relation. Copyright 2006 John Wiley & Sons, Ltd.
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