Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 110, Issue 1, Pages 56-60Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2006.09.002
Keywords
Combretum imberbe; triterpenoid; antibacterial; anti-inflammatory; anti-proliferative; cytotoxic
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Combretum imberbe is used widely in Africa inter alia for treating bacterial infections. In addition to four known triterpenoids, 1 alpha, 3 beta-dihydroxy-12-oleanen-29-oic (1), 1-hydroxy-12-olean-30-oic acid (2), 3,30-dihydroxyl-12-oleanen-22-one (3), and 1,3,24-trihydroxyl-12-olean-29-oic acid (4), a new pentacyclic triterpenoid (l alpha,23-dihydroxy- 12-oleanen-29-oic acid-3 beta-O-2,4-di-acetyl-L-rhamnopyranoside) 5 has been isolated through a bioassay-guided procedure from the leaves of Combretum imberbe. The structures of the compounds were elucidated on the basis of I D and 2D NMR experiments, as well as mass spectrometric data. All compounds isolated had moderate (62 mu g/ml) to strong (16 mu g/ml) antibacterial activity (MIC values) against Staphylococcus aureus and Escherichia coli, with 1 and 5 being most active. Compounds I and 5 also showed very strong inhibition of 3 alpha-hydroxysteroid dehydrogenase with an IC50 of 0.3 mu g/ml. Compound 5 indicated a moderate anti-proliferative (GI(50) = 16.5 and 13.2 mu g/ml) and cytotoxic activity (CC50 = 17.6 mu g/ml) against K-562, L-929 and HeLa cell lines, respectively. The results of this study give credence to the ethnomedicinal use of Combretum imberbe and expand our knowledge on the biological activity of its metabolites. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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