Journal
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Volume 175, Issue 5, Pages 458-463Publisher
AMER THORACIC SOC
DOI: 10.1164/rccm.200607-896OC
Keywords
motor activity; exercise; pulmonary disease; chronic obstructive; respiratory function tests; epidemiology
Categories
Ask authors/readers for more resources
Rationale: We have previously reported that regular physical activity reduces risk of chronic obstructive pulmonary disease (COPD) exacerbation. We hypothesized that higher levels of regular physical activity could reduce the risk of COPD by modifying smoking-related lung function decline. Objective: To estimate the longitudinal association between regular physical activity and FEV1 and FVC decline and COPD risk. Methods: A population-based sample (n = 6,790) was recruited and assessed with respect to physical activity, smoking, lung function, and other covariates, in Copenhagen in 1981-1983, and followed until 1991-1994. Mean level of physical activity between baseline and follow-up was classified into low, moderate, and high. FEV1 and FVC decline rates were expressed as milliliters per year. COPD was defined as FEV1/FVC <= 70%. Adjusted associations between physical activity and FEV1 and FVC decline, and COPD incidence, were obtained using linear and logistic regression, respectively. Results: Active smokers with moderate and high physical activity had a reduced FEV1 and FVC decline compared with those with low physical activity (relative change of +2.6 and +4.8 ml/yr of FEV1 P-for-trend = 0.006, and +2.6 and +7.7 ml/yr of FVC, P-for-trend < 0.0001, for the moderate and high physical activity group, respectively), after adjusting for all potential confounders and risk factors of lung function decline. Active smokers with moderate to high physical activity had a reduced risk of developing COPD as compared with the low physical activity group (odds ratio, 0.77; p = 0.027). Conclusions: This prospective study shows that moderate to high levels of regular physical activity are associated with reduced lung function decline and COPD risk among smokers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available