Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 52, Issue 30, Pages 7646-7665Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201301666
Keywords
amino acids; erythropoietin; glycoprotein; synthetic methods; total synthesis
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Funding
- National Institute of Health [HL25848]
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The total synthesis of a homogeneous erythropoietin (EPO), possessing the native amino acid sequence and chitobiose glycans at each of the three wild-type sites of Nglycosylation, has been accomplished in our laboratory. We provide herein an account of our decade-long research effort en route to this formidable target compound. The optimization of the synergy of the two bedrock sciences we now call biology and chemistry was central to the success of the synthesis of EPO.
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