Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 3, Pages 810-814Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201307232
Keywords
glycans; intracellular localization; multivalency; nanoparticles; quantum dots
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Funding
- EPSRC [EP/J002542/1]
- Biotechnology and Biological Sciences Research Council [BB/L014181/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/J002542/1, EP/J501426/1] Funding Source: researchfish
- BBSRC [BB/L014181/1] Funding Source: UKRI
- EPSRC [EP/J002542/1, EP/J501426/1] Funding Source: UKRI
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A series of glycan-coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a Trojan horse on bi-functionalized QDs to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.
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