Journal
BIOINFORMATICS
Volume 23, Issue 5, Pages 641-643Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btm011
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Funding
- NHLBI NIH HHS [HL80812, R01 HL080812] Funding Source: Medline
- NIDDK NIH HHS [DK067487, R01 DK067487] Funding Source: Medline
- NIEHS NIH HHS [ES09912, R01 ES009912] Funding Source: Medline
- NIGMS NIH HHS [R01 GM069430, R01 GM070683, GM070683] Funding Source: Medline
- PHS HHS [NIDDK 5803701, PA-02-110, NIDDK 66369-01] Funding Source: Medline
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R/qtlbim is an extensible, interactive environment for the Bayesian Interval Mapping of QTL, built on top of R/qtl (Broman et al., 2003), providing Bayesian analysis of multiple interacting quantitative trait loci ( QTL) models for continuous, binary and ordinal traits in experimental crosses. It includes several efficient Markov chain Monte Carlo (MCMC) algorithms for evaluating the posterior of genetic architectures, i.e. the number and locations of QTL, their main and epistatic effects and gene-environment interactions. R/qtlbim provides extensive informative graphical and numerical summaries, and model selection and convergence diagnostics of the MCMC output, illustrated through the vignette, example and demo capabilities of R (R Development Core Team 2006). Availability: The package is freely available from cran.r-project.org. Contact: byandell@wisc.edu or nyi@ms.soph.uab.edu.
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