Synthesis of (-)-Δ9-trans-Tetrahydrocannabinol:: Stereocontrol via Mo-catalyzed asymmetric allylic alkylation reaction

Delta(9)-THC is synthesized in enantiomericaly pure form, where all of the stereochemistry is derived from the molybdenum-catalyzed asymmetric alkylation reaction of the extremely sterically congested bis-ortho-substituted cinnamyl carbonate in high regio- and enantioselectivity.