Journal
GENETICS
Volume 175, Issue 3, Pages 1267-1274Publisher
GENETICS
DOI: 10.1534/genetics.106.064063
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Funding
- NIGMS NIH HHS [GM074244, R01 GM074244] Funding Source: Medline
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Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. BROMAN (2005) derived the two- and three-point haplotype probabilities for 2-way RIL; the former required hefty computation to infer the symbolic results, and the latter were strictly numerical. We describe a simpler approach for the calculation of these probabilities, which allowed us to derive the symbolic form of the three-point haplotype probabilities. We also extend the two-point results for the case of additional generations of intermating, including the case of 2-way intermated recombinant inbred populations (IRIP).
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