Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 42, Issue 3, Pages 410-419Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2006.09.020
Keywords
antitubercular agents; diarylmethanes; phenanthrenes
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Aminoalkyl derivatives of diarylmethanes were prepared using Grignard, Friedel-Crafts arylation and aminohydrochloride chain fort-nation reactions. These series of compounds were evaluated against Mycobacterium tuberculosis H37R nu, and showed the activity in the range of 6.25-925 mu g/mL. Effect of heteroaryl, anthracenyl and phenanthrene groups on diarylmethane pharmacophores for antitubercular activity is described. (c) 2006 Elsevier Masson SAS. All rights reserved.
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