Journal
PURINERGIC SIGNALLING
Volume 3, Issue 1-2, Pages 53-57Publisher
SPRINGER
DOI: 10.1007/s11302-006-9036-9
Keywords
giant cell formation; osteoclast; purinergic receptors
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Cells of the mononuclear phagocyte lineage fuse to form multinucleated giant cells and osteoclasts. Several lines of evidence suggest that P2 receptors, in particular P2X7, are involved in this process, although P2X7 is not absolutely required for fusion because P2X7-null mice form multinucleated osteoclasts. Extracellular ATP may be an important regulator of macrophage fusion.
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