Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 47, Issue 4, Pages 1177-1188Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2015.3120
Keywords
cancer invasion; collagen; extracellular matrix; matrix degradation; CD280; MRC2
Categories
Funding
- Danish Cancer Society
- Danish Medical Research Council
- Danish Cancer Research Foundation
- Lundbeck Foundation
- Novo Nordisk Foundation
- Danish National Research Foundation (Danish-Chinese Center for Proteases and Cancer)
- European Community's Seventh Framework Programme FP7 [201279]
- Lundbeck Foundation [R118-2012-11578] Funding Source: researchfish
- Novo Nordisk Fonden [NNF12OC0002353] Funding Source: researchfish
- The Danish Cancer Society [R90-A5823] Funding Source: researchfish
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The collagen receptor uPARAP/Endo180, the product of the MRC2 gene, is a central component in the collagen turnover process governed by various mesenchymal cells. Through the endocytosis of collagen or large collagen fragments, this recycling receptor serves to direct basement membrane collagen as well as interstitial collagen to lysosomal degradation. This capacity, shared only with the mannose receptor from the same protein family, endows uPARAP/Endo180 with a critical role in development and homeostasis, as well as in pathological disruptions of the extracellular matrix structure. Important pathological functions of uPARAP/Endo180 have been identified in various cancers and in several fibrotic conditions. With a particular focus on matrix turnover in cancer, this review presents the necessary background for understanding the function of uPARAP/Endo180 at the molecular and cellular level, followed by an in-depth survey of the available knowledge of the expression and role of this receptor in various types of cancer and other degenerative diseases.
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