Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 12, Issue 2, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.2714027
Keywords
laser thermal therapy; tissue response; optical frequency domain; laser damage
Funding
- NCI NIH HHS [1R21CA125560] Funding Source: Medline
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We present methods for visualizing the dynamic response of biological samples to laser-induced heating. Our approach utilizes optical frequency-domain imaging to detect, spatially localize, and monitor unique dynamic signatures that arise within zones of active tissue denaturation. Since this information is precisely registered with high-resolution (similar to 10 mu m) cross sectional images, regions of thermally destroyed tissue can be mapped in relation to pre-existing morphology. Using porcine esophageal specimens ex vivo, we demonstrate that the extent and evolution of laser thermal damage can be assessed in real time. (C) 2007 Society of Photo-Optical Instrumentation Engineers.
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