Journal
RNA
Volume 13, Issue 3, Pages 313-316Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.351707
Keywords
microRNA; RNA interference; genomic imprinting; noncoding RNAs
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Funding
- NIGMS NIH HHS [R01 GM071408, GM071408] Funding Source: Medline
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Although H19 was the first imprinted noncoding transcript to be identified, the function of this conserved RNA has remained unclear. Here, we identify a 23-nucleotide microRNA derived from H19 that is endogenously expressed in human keratinocytes and neonatal mice and overexpressed in cells transfected with human or mouse H19 expression plasmids. These data demonstrate that H19 can function as a primary microRNA precursor and suggest that H19 expression results in the post-transcriptional downregulation of specific mRNAs during vertebrate development.
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