Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 57, Issue 3, Pages 528-537Publisher
WILEY-BLACKWELL
DOI: 10.1002/mrm.21165
Keywords
T-1 mapping; T-2(*) mapping; proton density mapping; quantitative MRI; rapid quantification
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An imaging method called quantification of relaxation times and proton density by twin-echo saturation-recovery turbo-field echo (ORAPTEST) is presented as a means of quickly determining the longitudinal T-1 and transverse T-2* relaxation time and proton density (PD) within a single sequence. The method also includes an estimation of the B, field inhomogeneity. High-resolution images covering large volumes can be achieved within clinically acceptable times of 5-10 min. The range of accuracy for determining T-1, T-2*, and PD values is flexible and can be optimized relative to any anticipated values. We validated the experimental results against existing methods, and provide a clinical example in which quantification of the whole brain using 1.5 mm(3) voxels was achieved in less than 8 min.
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