Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 22, Issue 3, Pages 357-365Publisher
WILEY
DOI: 10.1359/jbmr.061114
Keywords
bone metabolism; brown adipose; circadian; glucocorticoid receptor; heat shock protein; liver; oxidative phosphorylation; white adipose
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Funding
- NIDCR NIH HHS [R21 DE016371] Funding Source: Medline
- NIDDK NIH HHS [P30 DK072476, DK072476] Funding Source: Medline
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The genes encoding the core circadian transcription factors display an oscillating expression profile in murine calvarial bone. More than 26% of the calvarial bone transcriptome exhibits a circadian rhythm, comparable with that observed in brown and white adipose tissues and liver. Thus, circadian mechanisms may directly modulate oxidative phosphorylation and multiple metabolic pathways in bone homeostasis.
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