Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 1, Pages 282-285Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201306037
Keywords
-alkylation; -branched aldehydes; DYKATt; enamine catalysis; organocatalysis
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- HPLC
- GC departments
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The first aminocatalyzed -alkylation of -branched aldehydes with benzyl bromides as alkylating agents has been developed. Using a sterically demanding proline derived catalyst, racemic -branched aldehydes are reacted with alkylating agents in a DYKAT process to give the corresponding -alkylated aldehydes with quaternary stereogenic centers in good yields and high enantioselectivities.
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