Journal
GENETICS
Volume 175, Issue 3, Pages 1533-1537Publisher
GENETICS
DOI: 10.1534/genetics.106.068130
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Funding
- NIGMS NIH HHS [GM057484, R01 GM057484] Funding Source: Medline
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Using a model system, we have shown that replicative senescence is accompanied by a 16-fold increase in base substitution and frameshift mutations near a chromosome end. The increase was dependent on error-prone polymerases required for the mutagenic response to DNA lesions that block the replication fork.
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