Journal
VACCINE
Volume 25, Issue 11, Pages 1962-1968Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2006.12.008
Keywords
pneumococcal protein D conjugate vaccine; ELISA IgG and opsonophagocytic antibodies; acute otitis media
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We explored the relationship between efficacy against acute otitis media (AOM) and both ELISA anti-polysaccharide IgG geometric mean concentrations (GMCs) and opsonophagocytic (OPA) geometric mean titres (GMTs) following primary and booster vaccination with pneumococcal protein D (Haemophilus influenzae-derived) conjugate vaccine. It was possible to distinguish between the OPA GMTs of low and high efficacy serotypes, however no such distinction was evident for ELISA GMCs. Also, there was a trend towards lower ELISA and OPA serotype-specific responses in subjects who developed AOM compared to controls. We conclude that serotype-specific OPA GMTs are an important endpoint to consider for evaluation of pneumococcal conjugate vaccines with respect to the protective efficacy against AOM (Study ID: 347414/NCT00119743). (c) 2006 Elsevier Ltd. All rights reserved.
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