Journal
BLOOD
Volume 109, Issue 5, Pages 2086-2088Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2006-06-031385
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Funding
- Intramural NIH HHS Funding Source: Medline
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Idiopathic CD4(+) T lymphocytopenia (ICL) is a rare heterogeneous disorder defined by CD4(+) T-cell counts below 300 cells/mu L in the absence of human immunodeficiency virus (HIV) infection or other known immune deficiency disorders. Here, we report the expansion of immature/transitional B cells in patients with ICL, which is associated with elevated serum levels of IL-7. Both the percentage of immature/transitional B cells and levels of IL-7 were inversely correlated with levels of CD4(+) T-cell counts and directly correlated to each other. Further analyses of B cells indicated that, in contrast to the activating effects of HIV disease on mature B cells, the expansion of immature/transitional B cells in patients with ICL occurred at the expense of memory B cells. These findings extend previous reports on primary immunodeficiencies as well as HIV disease by suggesting that CD4(+) T-cell lymphopenia has an impact on human B-cell development either directly or indirectly via the associated elevation of IL-7 levels.
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