Journal
NEUROIMAGE
Volume 35, Issue 1, Pages 140-148Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2006.11.009
Keywords
epilepsy surgery; synchrony; intracranial EEG; epileptogenic zone; seizure localization
Funding
- NINDS NIH HHS [5 K12 NS001698, R01 NS084142, K12 NS001698, K24 NS047551, 1 K08 NS48871 R1A1, K08 NS048871] Funding Source: Medline
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Abnormally strong functional linkage between cortical areas has been postulated to play a role in the pathogenesis of partial epilepsy. We explore the possibility that such linkages may be manifest in the interictal EEG apart from epileptiform disturbances or visually evident focal abnormalities. We analyzed samples of interictal intracranial EEG (ICEEG) recorded from subdural grids in nine patients with medically intractable partial epilepsy, measuring interelectrode synchrony using the mean phase coherence algorithm. This analysis revealed areas of elevated local synchrony, or hypersynchrony which had persistent spatiotemporal characteristics that were unique to each patient. Measuring local synchrony in a subdural grid results in a map of the cortical surface that provides information not visually apparent on either EEG or structural imaging. We explore the relationship of hypersynchronous areas to the clinical evidence of seizure localization in each case, and speculate that local hypersynchrony may be a marker of epileptogenic cortex, and may prove to be a valuable aid to clinical ICEEG interpretation. (c) 2006 Elsevier Inc. All rights reserved.
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