Journal
NANO LETTERS
Volume 7, Issue 3, Pages 596-601Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl0624723
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Funding
- NCI NIH HHS [U54CA119341, R01 CA107467, P50 CA089018, P50 CA89018, U54 CA119341, CA107467] Funding Source: Medline
- NIBIB NIH HHS [EB002100, R01 EB002100] Funding Source: Medline
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Deoxyribonucleic acid (DNA) oligonucleotides hybridize to matching DNA sequences in cells, as established in the literature, depending on active transcription of the target sequence and local molarity of the oligonucleotide. We investigated the intracellular distribution of nanoconjugates composed of DNA oligonucleotides attached to TiO2 nanoparticles, thus creating a locally increased concentration of the oligonucleotide. Two types of nanoconjugates, with oligonucleotides matching mitochondrial or nucleolar DNA, were specifically retained in mitochondria or nucleoli.
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