Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 17, Issue 5, Pages 1206-1210Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2006.12.024
Keywords
aminoglycosides; antibiotics; translation inhibitors; 2-deoxy-streptamine; ribosome; decoding site; 3,5-diamino-piperidine
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Funding
- NIAID NIH HHS [AI51105, R44 AI051104] Funding Source: Medline
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Aminoglycoside antibiotics target an internal RNA loop within the bacterial ribosomal decoding site. Here, we describe the synthesis and SAR of novel 3,5-diamino-piperidine derivatives as aminoglycoside mimetics, and show they act as inhibitors of bacterial translation and growth. (c) 2006 Elsevier Ltd. All rights reserved.
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