Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 110, Issue 1, Pages 92-98Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2006.09.021
Keywords
Euphorbia tirucalli; immunosuppressive; arthritis; flowcytometry; intracellular; IL-2; IFN-gamma
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The present study was undertaken to investigate the anti-arthritic activity of a biopolymeric fraction (BET) from plant Euphorbia tirucalli Boiss (Euphorbiaceae). The fraction showed dose dependent anti-arthritic activity and also showed in vivo immunomodulatory capacity being a major component in inhibiting arthritis. It caused suppression of CD4(+) and CD8(+) T cells, inhibition of intracellular Interleukin-2 (IL-2) and Interferon-gamma (IFN-gamma) by flowcytometry. It inhibited vascular permeability and the migration of leucocytes at the site of the insult. The oral LD0 in both rats and mice was more than 2000 mg/kg. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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