Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 30, Issue 3, Pages 267-269Publisher
PHARMACEUTICAL SOCIETY KOREA
DOI: 10.1007/BF02977604
Keywords
Cephalosporium sp.; pyrone derivative; 3-acetyl-7-hydroxy-5-methoxyl-3H-isobenzofuran-1-one; vermopyrone; 5-methylmellein; fungal metabolites
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A new pyrone derivative, 7, 9-dihydroxy-10-methyl-2H, 4aH, 6H, 10bH-pyrano[5,6-c][2]benzopyran-2,6-dione (1), was isolated from a culture broth of a strain of the fungus Cephalosporium sp. AL031, together with three known compounds, 3-acetyl-7-hydroxy-5-methoxyl-3Hisobenzofuran-1-one (2), vermopyrone (3), and 5-methylmellein (4). Their structures were elucidated by spectroscopic analysis including MS and 2D-NMR. Compounds 2, 3, and 4 are reported for the first time from fermentation broth of this fungus through the present study.
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