☆ 4.8 Article

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

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Journal

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 51, Issue 25, Pages 6140-6143

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201201358

Keywords

fragment-based screening; GTPases; K-Ras inhibitors; ligand design; NMR spectroscopy

Categories

Chemistry, Multidisciplinary

Funding

  1. US National Institutes of Health (NIH) [5DP1OD006933]
  2. ARRA [5RC2A148375]
  3. NCI SPORE in GI [5P50A095103-09]
  4. Lustgarten Foundation
  5. American Cancer Society [PF1110501CDD]
  6. Cancer Research UK [11566] Funding Source: researchfish
  7. NATIONAL CANCER INSTITUTE [DP1CA174419, RC2CA148375, P50CA095103] Funding Source: NIH RePORTER
  8. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007347] Funding Source: NIH RePORTER
  9. OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP1OD006933] Funding Source: NIH RePORTER

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