Journal
DEVELOPMENT
Volume 134, Issue 5, Pages 825-831Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.02788
Keywords
Drosophila; Notch; pigment cells; EGFR; Lz; combinatorial signaling
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Funding
- NEI NIH HHS [EY08152] Funding Source: Medline
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In the developing eye of Drosophila, the EGFR and Notch pathways integrate in a sequential, followed by a combinatorial, manner in the specification of cone-cell fate. Here, we demonstrate that the specification of primary pigment cells requires the reiterative use of the sequential integration between the EGFR and Notch pathways to regulate the spatiotemporal expression of Delta in pupal cone cells. The Notch signal from the cone cells then functions in the direct specification of primary pigment-cell fate. EGFR requirement in this process occurs indirectly through the regulation of Delta expression. Combined with previous work, these data show that unique combinations of only two pathways - Notch and EGFR - can specify at least five different cell types within the Drosophila eye.
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