Journal
CLINICAL OBSTETRICS AND GYNECOLOGY
Volume 50, Issue 1, Pages 277-294Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/GRF.0b013e31802f54c8
Keywords
polycystic ovary syndrome; obesity; adolescent; hyperandrogenism; lifestyle modification; weight loss
Categories
Funding
- NCRR NIH HHS [5 M01 RR00044] Funding Source: Medline
- NICHD NIH HHS [1 K23HD043881-01A1] Funding Source: Medline
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Polycystic ovary syndrome is frequently associated with obesity, with at least 50% of women with polycystic ovary syndrome demonstrating overweight or obesity defined by body mass index > 25 or > 30 kg/m(2). Overweight and obesity impact the clinical reproductive and metabolic features of the syndrome. Long-term complications of obesity such as cardiovascular risk and diabetes, as well as those over the short term in reproductive function, are significantly improved by lifestyle modification. Weight reduction is difficult to achieve over the long-term and programs designed for modest reduction in overall body weight (5% to 10%) with improvements in fitness are as effective as severe weight reduction in reducing metabolic disease and improving ovulatory potential. Further research is needed into the best approach for successful interventions that result in long-term sustained weight loss.
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